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目的:观察复方甘草酸苷联合西药治疗儿童过敏性紫癜的临床疗效。方法:将92例过敏性紫癜患儿分为观察组和对照组各46例。对照组采用西咪替丁注射液等西药对症治疗,观察组在对照组用药基础上给予静脉滴注复方甘草酸苷。观察2组相关炎症因子、免疫球蛋白及抗体水平的变化,评估临床疗效。结果:观察组总有效率为91.30%,高于对照组的71.74%,差异有统计学意义(P<0.05)。治疗后,2组干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)及白细胞介素-17(IL-17)水平均较治疗前降低(P<0.05),观察组的IFN-γ、IL-4及IL-17水平均比对照组下降更明显(P<0.05)。治疗后,2组IgA、C3水平均较治疗前降低(P<0.05),IgA/C3值均较治疗前减小(P<0.05);观察组的IgA、C3水平低于对照组(P<0.05),IgA/C3值小于对照组(P<0.05)。结论:复方甘草酸苷联合西药治疗儿童过敏性紫癜,可有效减轻炎症反应,改善患儿的免疫功能,效果优于单纯使用西药治疗。
Objective: To observe the clinical efficacy of compound glycyrrhizin combined with western medicine in the treatment of children with Henoch-Schonlein purpura. Methods: 92 cases of children with Henoch-Schonlein purpura were divided into observation group and control group, 46 cases each. The control group used cimetidine injection and other western medicine symptomatic treatment. The observation group was given IV infusion of compound glycyrrhizin on the basis of the control group. The changes of inflammatory cytokines, immunoglobulins and antibody levels in 2 groups were observed to evaluate the clinical effect. Results: The total effective rate in observation group was 91.30%, which was higher than that in control group (71.74%), the difference was statistically significant (P <0.05). After treatment, the levels of IFN-γ, IL-4 and IL-17 in two groups were lower than those before treatment (P <0.05) The levels of IFN-γ, IL-4 and IL-17 in the control group decreased more significantly than those in the control group (P <0.05). After treatment, the levels of IgA and C3 in both groups were lower than those before treatment (P <0.05), while the IgA / C3 values were lower than those before treatment (P <0.05). The levels of IgA and C3 in the observation group were lower than those in the control group 0.05), IgA / C3 values were lower than the control group (P <0.05). Conclusion: Compound glycyrrhizin combined with Western medicine in the treatment of Henoch-Schonlein purpura in children can effectively reduce the inflammatory reaction and improve the immune function in children. The effect is better than that of western medicine alone.