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对丙型肝炎病毒(HCV)抗体持续阳性而无肝病症状及体征者的临床处理尚有争论.为评定此类人员中肝病发病率以及了解循环中抗-HCV及血清中HCV RNA与肝组织学改变的相关性,本文报道了无症状抗-HCV阳性者(其中多数ALT正常)的肝活检结果.23例受试者中14例为男性,均经第二代酶联免疫吸附试验(ELISA-2)检测抗-HCV阳性,并经6个月以后再用重组免疫印迹法(RIBA)检测也阳性.此23例抗-HCV阳性者均进行体检、肝超声波扫描、常规肝功能试验及经皮肝活检,并于肝活检的当天收集血清标本用聚合酶联反应(PCR)检测HCV RNA.
There is still debate about the clinical management of patients with persistent positive hepatitis C virus (HCV) antibodies without symptoms and signs of liver disease.In order to assess the incidence of liver disease in these individuals and to understand the relationship between circulating anti-HCV and serum HCV RNA and liver histology In this paper, we report the results of liver biopsy in asymptomatic anti-HCV positive individuals, most of whom have normal ALT. Of the 23 subjects, 14 were male and all were tested by the second-generation enzyme-linked immunosorbent assay (ELISA- 2) positive for anti-HCV, and positive after 6 months by recombinant immunoblotting (RIBA) .These 23 cases of anti-HCV positive were examined by physical examination, liver ultrasound scan, routine liver function test and percutaneous Liver biopsies were collected and serum samples collected on the day of liver biopsy. HCV RNA was detected by polymerase chain reaction (PCR).