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近年来,随着免疫学、病毒学、分子生物学理论与技术的发展,抗心肌抗体与扩张型心肌病(DCM)的关系越来越受重视。抗心肌抗体的产生和参与DCM的资料累积已近50年。例如抗β肾上腺能受体抗体、抗ATP/ADP运载蛋白抗体、抗M胆碱能受体抗体和抗肌球蛋白重链抗体等,均可激活机体免疫系统使心肌细胞肿胀和坏死,是心脏受累的重要指标。本文主要对DCM与心肌自身抗体的相关发病机制作一综述。
In recent years, with the development of immunology, virology, molecular biology theory and technology, the relationship between anti-myocardial antibodies and dilated cardiomyopathy (DCM) has drawn more and more attention. Anti-myocardial antibody production and participation in DCM data accumulation for nearly 50 years. Such as anti-beta adrenergic receptor antibodies, anti-ATP / ADP carrier protein antibodies, anti-M cholinergic receptor antibodies and anti-myosin heavy chain antibodies, can activate the body’s immune system so that myocardial cell swelling and necrosis is the heart Important indicator of involvement. This article mainly reviews the pathogenesis of DCM and myocardial autoantibodies.