论文部分内容阅读
本实验用电感耦合等离子体发射光谱仪测定了33名正常人和63名冠心病人,(急性心肌梗塞25人,陈旧性心肌梗塞29人,慢性冠心病患者9人)血液中微量元素Mn、Cr、Cu、Zn的含量。发现1.对照组血清Mn为0.02145±0.0107ppm;Cr为0.0230±0.0167ppm;Cu为0.905±0.278ppm;Zn为0.0230±0.404ppm;Cu/Zn比值为0.973±0.395。与冠心病组血清Mn、Cr无明显差异。2.不同发作天数的急性心肌梗塞患者血清Cu、Zn和Cu/Zn比值的动态比较,结果表明,在急性心肌梗塞发作时可出现一过性的血清Cu升高,Zn降低,Cu/Zn比值高于对照组,随时间推移铜锌比值逐渐下降。3.陈旧性心肌梗塞和慢性冠心病者血清Cu、Zn和Cu/Zn比值远较对照组低,Cu/Zn比值<0.6的百分比远较对照组多(P<0.01),说明Cu/Zn比值降低可能是冠心病易患因素。4.用Feisher判别法将血清铜锌比值和其它主要易患因素作了横向比较,证明铜锌比值下降是冠心病主要易患因素,并结合国内外资料作了初步探讨。
In this experiment, the determination of trace elements Mn in blood of 33 normal subjects and 63 coronary heart disease patients (25 with acute myocardial infarction, 29 with old myocardial infarction and 9 with chronic coronary heart disease) by inductively coupled plasma atomic emission spectrometry Cr, Cu, Zn content. The results showed that: 1. The control group serum Mn was 0.02145 ± 0.0107ppm; Cr was 0.0230 ± 0.0167ppm; Cu was 0.905 ± 0.278ppm; Zn was 0.0230 ± 0.404ppm; Cu / Zn ratio was 0.973 ± 0.395. There was no significant difference of serum Mn and Cr between CHD group and coronary heart disease group. The dynamic comparison of serum Cu, Zn and Cu / Zn ratio in patients with acute myocardial infarction with different seizure days showed that there was a transient increase of serum Cu, Zn and Cu / Zn ratio in the onset of acute myocardial infarction Higher than the control group, the ratio of copper and zinc gradually decreased over time. The ratio of Cu, Zn and Cu / Zn in patients with old myocardial infarction and chronic coronary heart disease was much lower than that in control group. The percentage of Cu / Zn ratio <0.6 was much more than that of control group (P <0.01) Reduce the risk of coronary heart disease may be factors. Using Feisher’s discriminant method to compare serum copper-zinc ratio with other major risk factors, it is proved that the decrease of copper-zinc ratio is the main predisposing factor for coronary heart disease.