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抗癫痫药物的致畸作用虽有很多研究,但至目前还没有肯定的结论。作者通过对接受药物治疗的癫痫母亲的172例婴儿进行前瞻性研究,以发现接受药物治疗癫痫的母亲的子女畸形发生率高的主要危险因素。结果在172例接受药物治疗的癫痫母亲的婴儿中,24例有大及/或小畸形,2例有多种畸形。畸形的发生率14.0%;其中单一药物治疗的31例畸形发生率6.5%,多种药物治疗的141例畸形发生率15.6%。后者的药物评分较前者高(P=0.01)。畸形的发生率与不同药物有关,苯妥英(PHT)14.6%,苯
Although there are many studies on the teratogenic effects of antiepileptic drugs, up to now there is no definite conclusion. The prospective study of 172 infants who received medical treatment of epilepsy mothers found that the main risk factors for the high incidence of deformity in their children were those who received medication for epilepsy. Results Of 172 infants with medication-treated epilepsy mothers, 24 had large and / or small deformities and two had multiple deformities. The incidence of deformity was 14.0%. The incidence of deformity was 6.5% in 31 cases treated with single drug and 141 cases with multiple medical treatment were 15.6%. The latter’s drug score than the former (P = 0.01). The incidence of deformity and different drugs, phenytoin (PHT) 14.6%, benzene