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十余年来,随着异烟肼预防性治疗的普遍应用,所见副作用也日趋增多。资料报告约10％服药者出现一过性转氨酶升高,严重肝脏损害少见,因肝炎致死者仅5例。作者于五年内观察到14例经组织学证实的异烟肼肝炎,其中死于急性肝功能衰竭者3例。男:女=3:11,年龄为19—66岁,9例50岁以上,8例系经绝后妇女,后者2例死亡。3例患者再次服用异烟肼,2例迅速激发肝炎,1例于两天内出现转氨酶异常。文中认为异烟肼引起肝脏损害的发生原理是过敏反应,其理由是:发病与用药剂量或时间无关,挑拨试验立即诱发肝炎,有人发现异烟肼肝炎患者可用异烟肼引起淋巴细胞转化,但此点未被其他学者复证。组织学改变和病毒性肝炎相似,自轻型的斑点
More than ten years, with the widespread use of isoniazid prophylaxis, the side effects seen are also increasing. Data reported about 10% of those who take medication appeared transient transaminase increased, severe liver damage rare, only five cases of hepatitis caused by death. The authors observed in 14 patients histologically confirmed isoniazid hepatitis, of which 3 died of acute liver failure. Male: Female = 3: 11, aged 19-66 years old, 9 cases over 50 years of age, 8 cases of post-partum women, the latter two died. In 3 patients, isoniazid was taken again, 2 patients were rapidly challenged with hepatitis, and 1 patient had abnormal aminotransferase in two days. The article considers that the principle of isoniazid-induced liver damage is anaphylaxis, the reason is: the incidence and dose or time has nothing to do, provoke the provocation test immediately induced hepatitis, it was found that isoniazid in patients with isoniazid can cause lymphocyte transformation, This point has not been reexamined by other scholars. Histological changes Similar to viral hepatitis, since light spots