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目的探讨抗菌药物对幽门螺杆菌(Hp)感染胃溃疡患者血清中胃蛋白酶原水平的影响及治疗效果。方法选取厦门大学附属第一医院2015年10月—2016年9月收治并确诊Hp阳性胃溃疡患者86例,随机分为对照组(奥美拉唑治疗)和观察组(奥美拉唑和阿莫西林联合治疗),每组43例,比较两组治疗前后的血清胃蛋白酶原Ⅰ(PGⅠ)、PGⅡ水平,并观察两组的治疗效果。结果两组治疗前的血清PGⅠ、PGⅡ水平比较,差异无统计学意义(P>0.05);治疗后两组患者的血清PGⅠ、PGⅡ水平明显下降,其中观察组PGⅠ、PGⅡ水平分别为(137.10±12.27)μg/L、(8.69±1.09)μg/L,明显低于对照组(P<0.05),同时观察组患者的治疗总有效率为95.35%,显著高于对照组的74.42%(P<0.05)。结论抗菌药物治疗Hp感染胃溃疡患者具有更好的疗效,并可有效的降低血清中PGⅠ、PGⅡ的水平。
Objective To investigate the effect of antibacterials on serum levels of pepsinogen in patients with Helicobacter pylori (Hp) infection and their therapeutic effects. Methods 86 cases of Hp-positive gastric ulcer admitted to the First Affiliated Hospital of Xiamen University from October 2015 to September 2016 were randomly divided into control group (omeprazole treatment) and observation group (omeprazole and A Moxillin combined therapy), 43 cases in each group. The levels of PGⅠ and PGⅡ were compared between the two groups before and after treatment, and the therapeutic effects of the two groups were observed. Results There was no significant difference in the serum levels of PGⅠ and PGⅡ between the two groups before treatment (P> 0.05). After treatment, the levels of serum PGⅠ and PGⅡ were significantly decreased in both groups. The levels of PGⅠ and PGⅡ in the two groups were (137.10 ± 12.27 μg / L and 8.69 ± 1.09 μg / L, respectively, which was significantly lower than that of the control group (P <0.05). The total effective rate of the observation group was 95.35%, significantly higher than that of the control group (74.42%, P < 0.05). Conclusion Antimicrobial agents have better curative effect in the treatment of patients with gastric ulcer infected with Hp, and can effectively reduce the levels of PGⅠ and PGⅡ in serum.