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目的 :探讨各型肝病患者外周血TGF -α水平及其临床意义。方法 :取 130例肝病患者 (包括急性黄疸型肝炎 2 0例 ,轻型慢性乙型肝炎 2 9例 ,慢性重型肝炎 2 2例 ,肝炎肝硬化 32例及原发性肝癌 2 7例 )入院时血清 (- 30℃下保存 )以RIA法作TGF -α检测。结果 :急性黄疸型肝炎为 17 6 1± 7 90 pg/ml,轻型慢性乙型肝炎为 12 6 6± 4 4 3pg/ml,慢性重型肝炎为10 754 80pg/ml,肝炎肝硬化为 11 4 5± 7 0 7pg/ml原发性肝癌为 19 4 2± 19 12pg/ml。均明显高于对照组 6 4 6± 2 15pg/ml。而原发性肝癌组明显高于肝炎肝硬化组。急性黄疸肝炎组明显高于慢性乙型肝炎组 ;原发性肝癌与急性黄疸型肝炎两组间无显著性差异。慢性乙型肝炎 ,肝炎肝硬化及慢性重型肝炎三组间比较无显著性差异。结论 :血清TGF -α在肝细胞急性炎症过程及肝细胞癌的形成中明显表达 ,并在肝硬化向原发化性肝癌转化的过程中 ,TGF -α有可能成为临床监测指标之一。
Objective: To investigate the level of TGF-α in peripheral blood of patients with various liver diseases and its clinical significance. Methods: 130 patients with liver disease (including 20 cases of acute jaundice hepatitis, 29 cases of light chronic hepatitis B, 22 cases of chronic severe hepatitis, 32 cases of liver cirrhosis and 27 cases of primary liver cancer) (Stored at -30 ° C) for TGF-α assay by RIA. Results: Acute jaundice hepatitis was 17 6 1 ± 7 90 pg / ml, light-cured chronic hepatitis B was 126 643 pg / ml, chronic severe hepatitis was 10 754 80 pg / ml and hepatitis cirrhosis was 11 45 ± 70 7 pg / ml of primary liver cancer was 19 42 ± 19 12 pg / ml. Were significantly higher than the control group 6 4 6 ± 2 15pg / ml. The primary liver cancer group was significantly higher than hepatitis cirrhosis group. Acute jaundice hepatitis group was significantly higher than the chronic hepatitis B group; no significant difference between the two groups of primary liver cancer and acute jaundice hepatitis. Chronic hepatitis B, hepatitis cirrhosis and chronic severe hepatitis were no significant difference between the three groups. Conclusion: Serum TGF-α is highly expressed in hepatocellular acute inflammatory process and hepatocellular carcinoma. TGF-α may be one of the clinical indicators in the process of cirrhosis into primary hepatocellular carcinoma.