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实验证明国产米托蒽醌无论静脉、腹腔、皮下或灌胃给药,对小鼠S_(180)均有强的抑瘤作用,化疗指数为6.05。本品对小鼠P_(388)白血病、L_(1210)白血病、肝癌腹水型及lewis肺癌的抗瘤活性高于或相当于阿霉素。
The experiment proved that domestic mitoxantrone has strong anti-tumor effect on mouse S 180, regardless of intravenous, intraperitoneal, subcutaneous or intragastric administration. The chemotherapy index is 6.05. The anti-tumor activity of this product against mouse P_(388) leukemia, L_(1210) leukemia, hepatocellular carcinoma ascites type, and Lewis lung cancer is higher than or equivalent to doxorubicin.