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目的:利用水貂呕吐模型观察连翘的止呕作用。方法:(1)将水貂随机分为6组,第1组灌胃蒸馏水15ml/kg,第2组腹腔注射昂丹司琼2mg/kg,第3、4、5、6组分别ig连翘水煎液3g/kg、10g/kg、15g/kg和连翘醇提液10g/kg;第2组给药后0.5h,其余五组给药后1h,分别ip顺铂7.5mg/kg。记录各组动物在给予顺铂后6h内的呕吐潜伏期、干呕和呕吐次数。(2)将水貂随机分为3组,第1组ig蒸馏水15ml/kg,第2组ip甲氧氯普胺4mg/kg,第3组ig连翘水煎液10g/kg。第2组给药后0.5h,其余2组给药后1h,分别皮下注射阿朴吗啡1.0mg/kg。记录各组动物在给予阿朴吗啡后6h内的呕吐潜伏期、干呕和呕吐次数。(3)将水貂随机分为3组,第1组ig蒸馏水15ml/kg,第2组ip甲氧氯普胺4mg/kg,第3组ig连翘水煎液10g/kg。各组给药后0.5hi,.g.硫酸铜40mg/kg,记录各组动物在给予硫酸铜后6h内的呕吐潜伏期、干呕和呕吐次数。结果:连翘能够延长顺铂、阿朴吗啡、硫酸铜所致的水貂呕吐潜伏期,减少干呕次数。结论:连翘对上述三种经典催吐剂导致的水貂呕吐模型均具有止呕作用。
Objective: To observe the antiemetic effect of forsythia by using mink vomiting model. Methods: (1) The minks were randomly divided into 6 groups, the first group was given distilled water 15ml / kg, the second group was injected with 2mg / kg of ondansetron, the third, Decoction of 3g / kg, 10g / kg, 15g / kg and forsythia alcohol extract 10g / kg; Group 2 0.5h after administration, the remaining five groups after administration 1h, ip cisplatin 7.5mg / kg. The latency, vomiting and vomiting of vomiting within 6 hours after cisplatin administration were recorded in each group of animals. (2) The minks were randomly divided into 3 groups, the first group ig distilled water 15ml / kg, the second group ip metoclopramide 4mg / kg, the third group ig Liaoqiao decoction 10g / kg. 0.5 h after administration in group 2 and 1 h after administration in the other 2 groups, apomorphine 1.0 mg / kg was injected subcutaneously. The latency, vomiting and vomiting of vomiting within 6 hours after apomorphine administration were recorded in each group of animals. (3) The minks were randomly divided into three groups, the first group of ig distilled water 15ml / kg, the second group ip metoclopramide 4mg / kg, the third group ig Forsythia decoction 10g / kg. Each group after administration 0.5hi ,. g copper sulfate 40mg / kg, recorded in each group of animals within 6h after the administration of copper vomiting latency, retching and vomiting. Results: Forsythia can prolong the incubation period of vomiting caused by cisplatin, apomorphine and copper sulfate, and reduce the number of retching. Conclusions: Forsythia suspensa has a vomiting effect on the mink vomiting model induced by the three classic emetic agents mentioned above.