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红霉素临床上多用于耐青霉素的严重金葡萄感染的肺炎、败血症、伪膜性肠炎、急性乳腺炎、多发性疖、痈等,红霉素在pH7时最稳定,在碱性条件下抗菌效能较强,pH<4时几乎完全失效,人体胃液呈强酸性(pH约1～1.5),为此在服用红霉素时应伴服碳酸氢钠,可保证红霉素免被胃酸破坏。据我院病历调查,不少患者在服用红霉素时,同服中成药治疗并发症或其它疾病。然而,哪些中成药会降低红霉素的抗菌作用呢?现讨论如下。中成药山楂丸、保和丸、五味子丸、冰霜梅苏丸等内含维生素C、枸橼酸、苹果酸、酒石酸等,均
Erythromycin is clinically used for penicillin-resistant severe grapevine-infected pneumonia, sepsis, pseudomembranous colitis, acute mastitis, multiple hemorrhoids, sputum, etc. Erythromycin is most stable at pH 7 and is antibacterial under alkaline conditions. Stronger potency, almost complete failure at pH <4, human gastric juice is strongly acidic (pH about 1 ~ 1.5), for this reason, when taking erythromycin should be used in conjunction with sodium bicarbonate, erythromycin can be protected from gastric acid damage. According to medical records in our hospital, many patients take erythromycin to treat complications or other diseases with proprietary Chinese medicines. However, which of the proprietary Chinese medicines will reduce the antibacterial effect of erythromycin is discussed below. Chinese medicines such as Shanzhu Pills, Baohe Pills, Wuweizi Pills, and Frozen Meisu Pills contain vitamin C, citric acid, malic acid, tartaric acid, etc.