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文章简介黄脂菌素及其若干多环吨酮类抗生素,是一类具有独特的吨酮结构和显著抗真菌及抗肿瘤活性的微生物天然产物,但该类抗生素中与发挥生物活性有关的吨酮的生物合成机制一直不清楚。本研究中,研究人员通过体内遗传、体外生化实验手段,揭示了黄脂菌素生物合成中黄素单加氧酶Xan O4负责催化蒽醌到吨酮的转化,发现XanO 4催化吨酮生物合成过程中发生了连续
INTRODUCTION Lactobacillus and some polycyclotetralone antibiotics are a kind of natural products of microorganisms with unique ton-ketone structure and significant anti-fungal and anti-tumor activity. However, these antibiotics are often used in biological activities The mechanism of ketone biosynthesis has not been clear. In this study, researchers through in vivo genetic, in vitro biochemical experiments revealed that the xanthogenin biosynthesis Xanthin monooxygenase Xan O4 is responsible for the catalytic anthraquinone to tons of ketone conversion and found XanO 4 catalyzed tons ketone biosynthesis process Continuous occurred