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目的探讨非酒精中毒性Wernicke脑病的病因、诊断和治疗。方法报道 2例非酒精中毒性Wernicke脑病非典型病例的临床资料 ,并结合文献进行分析。结果 2例患者均无酒精滥用史 ,无其他营养不良如癌症或长期住院史。但1例有剧吐或反复静脉输液史。临床上均出现发热、头痛、呕吐、精神紊乱。早期误诊为病毒性脑炎。用维生素B1治疗数小时～数天症状明显改善。结论在非酒精中毒患者中Wernicke脑病少见且为易被忽视的威胁生命的疾病。临床诊断依赖于医生的高度警惕性 ,维生素B1治疗后症状可快速逆转。
Objective To investigate the etiology, diagnosis and treatment of non-alcoholic Wernicke encephalopathy. Methods The clinical data of 2 atypical cases of non-alcoholic Wernicke’s encephalopathy were reported and analyzed in combination with the literature. Results None of the two patients had a history of alcohol abuse and had no other malnutrition such as cancer or long-term hospitalization. However, 1 case had pharynx or repeated intravenous infusion history. Clinical fever, headache, vomiting, mental disorders. Early misdiagnosed as viral encephalitis. Vitamin B1 treatment for several hours ~ a few days significantly improved symptoms. Conclusions Wernicke’s encephalopathy is a rare and neglected life-threatening disorder among non-alcoholic patients. Clinical diagnosis depends on the doctor’s vigilance, symptoms can be quickly reversed after treatment with vitamin B1.