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目的:观察围手术期成份输血对胃癌患者炎症反应的影响。方法:随机选择胃癌病人分为3组:对照组,压积红细胞组,全血组。分别采用ELISA法和放免法检测患者术前及术后低1、3、7、14天血清中IL-6、IL-10、COX-2及PGE2含量。结果:手术后第一周是感染发生的主要时期,两周后,炎症反应基本消失,输血能升高患者血清中的促炎因子,降低抗炎因子IL-10的表达,但相对于输异体全血,输成份血能降低血清中COX-2、PGE2、IL-6的含量,升高血清IL-10的含量。结论:胃癌患者围手术期输血能促进机体的炎症反应,成份输血致炎效果弱于输异体全血。
Objective: To observe the effect of perioperative blood transfusion on the inflammatory response in patients with gastric cancer. Methods: Patients with gastric cancer were randomly divided into three groups: control group, hematocrit erythrocyte group and whole blood group. Serum levels of IL-6, IL-10, COX-2 and PGE2 were measured by ELISA and radioimmunoassay before, 1, 3, 7 and 14 days after operation. Results: The first week after surgery was the main period of infection. After two weeks, the inflammatory reaction basically disappeared. Blood transfusion increased serum proinflammatory cytokines and decreased the expression of anti-inflammatory cytokine IL-10. However, Whole blood, blood transfusion can reduce serum levels of COX-2, PGE2, IL-6, increased serum IL-10 levels. Conclusion: Perioperative blood transfusions in gastric cancer patients can promote the body’s inflammatory response, and the effect of blood transfusion is weaker than that of allogeneic whole blood.