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测定了４０例健康人群和３３例皮肌炎患者２４ｈ尿肌酸肌酐水平，并按Ｒｏｓｅ肌无力程度分级法将患者分为肌力Ⅱ级、Ⅲ～Ⅳ和Ⅴ～Ⅵ级３组。结果显示，皮肌炎患者各组２４ｈ尿肌酸明显高于健康对照组（Ｐ＜０．００１），但患者组间２４ｈ尿肌酸水平无显著性差异（Ｐ＞０．０５），２４ｈ尿肌酸与肌无力程度间亦无明显相关关系（Ｐ＞０．０５）。结果提示２４ｈ尿肌酸水平作为皮肌炎诊断依据之一尚且可靠，但用以观察病情变化尚欠准确。
The creatine and creatinine levels of 24h urine were measured in 40 healthy subjects and 33 dermatomyositis patients. The patients were divided into 3 groups of muscle strength Ⅱ, Ⅲ ~ Ⅳ and Ⅴ ~ Ⅵ according to Rose Muscular Insufficient Grading method. The results showed that the creatine excretion of 24h group was significantly higher than that of healthy control group (P <0.001), but there was no significant difference (P> 0.05) between 24h group and 24h group There was no significant correlation between creatine and muscle weakness (P> 0.05). The results suggest that 24h urine creatine level as a basis for the diagnosis of dermatomyositis is still reliable, but to observe the changes in the condition is not accurate.