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在不同途径和剂量的硫酸镁治疗重度妊娠中毒症患者时,随机测定血清镁浓度15次,系统测定血清镁浓度10例,并结合临床观察,我们认为采用大剂最硫酸镁治疗重度妊毒症是有效而安全的;小剂量则不能达到有效水平。因此首次硫酸镁剂量应以静脉与肌肉联合途径给予10～14克,以迅速达到血清镁有效浓度;以后用静脉滴注作为维持量,使24小时总量至少达30克。采用大剂量硫酸镁治疗时,观察膝反射对剂量的调节和镁中毒的预防是非常重要的。
In different ways and doses of magnesium sulfate in patients with severe gestosis, serum magnesium concentration was determined randomly 15 times, the system of serum magnesium concentration in 10 cases, combined with clinical observation, we believe that the use of large doses of magnesium sulfate in patients with severe pregnancy-induced toxicity Is effective and safe; small doses can not reach the effective level. Therefore, the first dose of magnesium sulfate should be intravenous and muscular route of administration of 10 to 14 grams, to quickly reach the serum magnesium concentration; after intravenous infusion as a maintenance volume, so that the total 24 hours total of at least 30 grams. The use of high doses of magnesium sulfate treatment, the observation of knee reflex dose adjustment and prevention of magnesium poisoning is very important.