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目的：分析不同方式分期治疗前和TNM分期治疗前后各期血清Ⅳ型胶原（CIV）水平的变化。方法：采用放射免疫测定法检测30例鼻咽癌患者放射治疗后CIV水平，与50例正常人作比较。结果；鼻咽癌患者血清CIV水平与正常人比较无显著性差异（P＞0．05），鼻咽癌患者放射治疗前后血清CIV水平无统计学意义（P＞0．05），不同方式分期时各期在放射治疗前发TNM分期时各期在放射治疗前后血清CIV水平均无显著性差异（均P＞0．05）。结论：本组结果提示检测血清CIV水平作为判断鼻咽癌病情发放射治疗疗效的指标不一定可靠。
Objective: To analyze the changes of serum level of type Ⅳ collagen (CIV) before and after treatment in different ways by staging and TNM staging. Methods: Radioimmunoassay was used to detect the level of CIV in 30 patients with nasopharyngeal carcinoma after radiotherapy, compared with 50 healthy controls. Results There was no significant difference in serum CIV levels between NPC patients and normal controls (P> 0.05). There was no significant difference in serum CIV levels between NPC patients before and after radiotherapy (P> 0.05) There were no significant differences in serum CIV levels between before and after radiotherapy (P> 0.05). Conclusion: The results of this group suggest that the detection of serum CIV levels as indicators to determine the efficacy of radiation therapy for nasopharyngeal carcinoma may not be reliable.