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Aim:To investigate the possible synergism of hydrochlorothiazide andnitrendipine on reducing both blood pressure(BP)and blood pressure variabil-ity(BPV)in spontaneously hypertensive rats(SHR).Methods:Seventy ani-mals were randomly divided into seven groups.The doses were 5 and 10 mg/kgfor nitrendipine,10 and 20 mg/kg for hydrochlorothiazide and 10+5,20+10mg/kg,respectively,for the combination of these two drugs and 0.8% carboxym-ethylcellulose as control.The drugs were given via a catheter of gastric fistula.BP was then continuously recorded for 5h from 1h before drug administrationto the end of 4th hour after drug administration,in conscious and freely movingrats.Results:The effects on both BP and BPV reduction of the combination ofhydrochlorothiazide and nitrendipine were greater than the single drug in SHR.The two drugs possessed an obvious synergism on both systolic blood pressure(q=1.79 with small dose and q=1.23 with large dose)and systolic blood pres-sure variability reduction(q=1.79 with small dose and q=1.39 with large dose)in SHR.Conclusion:The present work clearly demonstrated that there was asynergistic effect between hydrochlorothiazide and nitrendipine in lowering andstabilizing BP in SHR.