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目的:探讨维吾尔族尿路结石发病相关的危险因素,为新疆维吾尔自治区维吾尔族人群尿路结石治疗及预防提供科学依据。方法:我们对2012年3月~2013年1月新疆维吾尔自治区人民医院泌尿外科收治的100例维吾尔族尿路结石住院患者(尿路结石组)及同期100例非尿路结石患者(对照组)采用基于医院的1∶1配对病例进行对照研究。内容涉及一般人口学特征、饮水量、膳食习惯及结构、遗传家族史等。采用非条件logistic回归进行数据分析。结果:尿路结石组和对照组配比条件均衡可比,单因素logistic回归分析共有9个变量有统计学意义,但最终进入模型的因素有:饮水量500~1 500ml(OR=0.129,95%CI:0.044~0.380)、饮水量1 500ml以上(OR=0.161,95%CI:0.060~0.434)、摄入动物内脏(OR=4.611,95%CI:2.058~10.329)、甜食(OR=2.539,95%CI:1.129~5.709)、水果(OR=0.372,95%CI:0.168~0.824)、出汗习惯(OR=6.732,95%CI:2.994~15.138)、结石病家族史(OR=9.273,95%CI:2.622~32.797)等。结论:日饮水量<500ml、喜欢吃动物内脏及甜食、有经常出汗习惯以及结石病家族史是维吾尔族尿路结石发病的危险因素。平时多饮水、多食水果是尿路结石发病的保护因素。
Objective: To investigate the risk factors associated with urolithiasis in Uighur ethnic group and provide scientific evidences for the treatment and prevention of urolithiasis in Uighur ethnic groups in Xinjiang Uygur Autonomous Region. Methods: From March 2012 to January 2013, 100 Uighur urolith patients (urolithiasis) and 100 non-urolithiasis patients (control group) admitted to Department of Urology, People’s Hospital of Xinjiang Uygur Autonomous Region from January 2012 to January 2013 were enrolled in this study. A hospital-based 1: 1 matched case-control study was used. It covers general demographic characteristics, drinking water, dietary habits and structure, and genealogical family history. Non-conditional logistic regression was used for data analysis. Results: There were 9 balanced variables in urinary calculus group and control group. There were 9 variables in the logistic regression analysis, but the final factors of the model were as follows: drinking water 500-1 500ml (OR = 0.129, 95% (OR = 4.61, 95% CI: 2.058 ~ 10.329), sweet food (OR = 2.539, CI = 0.044-0.380), water intake more than 1500ml (OR = 0.161,95% CI: 0.060-0.434) (OR = 6.732, 95% CI: 2.994-15.138), family history of stone disease (OR = 9.273, 95% CI 1.129-5.709, OR = 0.372, 95% CI 0.168-0.824) 95% CI: 2.622 ~ 32.797) and so on. Conclusion: Daily drinking water <500ml, like to eat animal offal and sweets, frequent sweating habits and family history of stone disease are the risk factors of Uighur urolithiasis. Usually drink more water, eat more fruit is the protective factors of urinary tract stones.