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很多试验已证明急性心肌梗塞(AMI)患者使用溶栓治疗较之用常规治疗不增加中风的危险。但使用不同溶栓制剂和抗凝治疗的病人中,各类中风的发生率以及这些药物与中风危险因子的综合作用尚不很清楚。病人和方法 AMI 症状发生6小时内住院且资料完整者20768例。随机分为:①链激酶组:以150万 U30～60min 内静脉输入,共10396例;②组织型纤溶酶原激活剂(t-PA)组:以100mg 在3小时内静脉输入,共10372例。另外全部病例中有10361例用肝素12500U每天2次皮下注射;10407例不用肝素。91%的病人并使用阿司匹林。
Many trials have demonstrated that thrombolytic therapy in patients with acute myocardial infarction (AMI) does not increase the risk of stroke compared with conventional treatment. However, the use of different thrombolytic agents and anticoagulants in patients, the incidence of various types of stroke and the combined effect of these drugs and stroke risk factors is not yet clear. Patients and Methods AMI symptoms occurred within 6 hours of hospitalization and data were complete 20,768 cases. Randomly divided into: ① streptokinase group: 1.5 million U30 ~ 60min intravenous infusion, a total of 10396 cases; ② tissue-type plasminogen activator (t-PA) group: intravenous infusion of 100mg within 3 hours, a total of 10372 example. In addition, 10361 patients were injected subcutaneously twice daily with heparin 12500U in 1036 cases without heparin. 91% of patients and use aspirin.