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在20个ICU病房中采用随机双盲法,对甲氰咪呱持续静脉滴注能否能有效地防止应激性溃疡的发生和是否会伴有院内感染性肺炎发病率的升高进行研究,并设安慰剂组作对照。131例病人,其中甲氰咪呱组65例,安慰剂组66例。病人年龄均大于16岁。女性病人均不在哺乳期和妊娠期。每例病人均有一种或一种以上的应激打击。给药前12小时内均未用过H_2受体拮抗剂和与出凝血相关的药物。观察用药物均溶解
A randomized, double-blind method was used in 20 ICU wards to study whether continuous intravenous infusion of cimetidine can effectively prevent the occurrence of stress ulcer and whether it will be associated with the increased incidence of nosocomial pneumonia, And placebo group for control. 131 patients, including 65 cases of cromolyn group, placebo group of 66 cases. Patients are older than 16 years of age. Female patients are not breast-feeding and pregnancy. Each patient has one or more stress blows. None of the H 2 receptor antagonists and agents associated with coagulation were used within 12 hours prior to dosing. Observed drugs are dissolved