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硝苯吡啶(NF)与醋丁洛尔(Acebutolol,AB)合并用药对高血压和心绞痛比各自单用更有效,且AB的主要代谢产物二醋洛尔(Diacetolol)亦有药理活性。本文探讨含10mg 微晶NF 和100mg AB 的新片剂(A)的药动学规律,并分别与单独服用10mg NF 片(B)、20mg NF 片(D)和100mg AB(C)片进行比较。受试者为健康男女各半计12人,服药一次,连用5天以达稳态动力学。服药后定时采集血和尿样,并检测药物及
Nifedipine (NF) combined with Acebutolol (AB) is more effective than either alone or in combination with Acetophenol (AB), and Diacetolol, a major metabolite of AB, is also pharmacologically active. This article explores the pharmacokinetics of a new tablet (A) containing 10 mg of microcrystalline NF and 100 mg of AB and compares them with 10 mg of NF tablets (B), 20 mg of NF tablets (D) and 100 mg of AB (C) tablet alone . Subjects for the health of men and women each half 12 people, once a day, once every 5 days to reach steady-state kinetics. Take blood and urine samples regularly after taking the medicine, and test the medicine and