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目的研究卵巢上皮性肿瘤中黏蛋白MUC2和MUC5AC的表达,探讨它们在卵巢上皮性肿瘤恶性进展中的作用及其临床意义。方法采用免疫组化方法SP法检测20例良性、23例交界性和37例恶性卵巢上皮性肿瘤中黏蛋白MUC2和MUC5AC的表达。结果黏蛋白MUC2和MUC5AC表达水平随卵巢黏液性肿瘤恶性程度的增加而表达增高。黏蛋白MUC2的表达与肿瘤的病理分级和临床分期密切相关,而黏蛋白MUC5AC与病理分级和临床分期无关。结论卵巢黏液性肿瘤发生早期肿瘤细胞即有胃型和肠型的分化,并且随着肿瘤的恶性进展持续存在。检测黏蛋白MUC2的表达可作为预测卵巢癌预后的有价值的指标。
Objective To investigate the expression of mucin MUC2 and MUC5AC in ovarian epithelial neoplasms and to explore their roles in the malignant progression of ovarian epithelial neoplasms and their clinical significance. Methods Immunohistochemical SP method was used to detect the expressions of mucin MUC2 and MUC5AC in 20 benign, 23 borderline and 37 malignant ovarian epithelial neoplasms. Results Mucin MUC2 and MUC5AC expression increased with the malignant degree of ovarian mucinous tumors. The expression of mucin MUC2 is closely related to the pathological grading and clinical stage of the tumor, whereas mucin MUC5AC has no relation with the pathological grade and clinical stage. Conclusions The early stage of ovarian mucinous tumor has the differentiation of stomach and intestine, and it persists with the malignant progress of the tumor. Detection mucin MUC2 expression can be used as a prognostic value of ovarian cancer a valuable indicator.