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3.抑制试验地塞米松抑制试验:由于本品为一种合成的皮质醇同系物,半衰期较长,其代谢物仅占类固醇总排出量的一小部分,较其它同系物为优,故选作抑制试验用药物。 (1)隔夜地塞米松(单一剂量)试验:令受试者于晚11时服地塞米松,成人1毫克或0.5—1毫克/米~2(如已服大仑丁或苯巴比妥等药者,应予2毫克),儿童10微克/公斤。并服非巴比妥类镇静药(如安定)。翌晨8时抽血,测血浆皮质醇浓度。
3. Inhibition test dexamethasone inhibition test: Since this product is a synthetic cortisol homologues, half-life longer, the metabolites accounted for only a small part of the total steroid output, better than other homologues, so the election Suppression test drugs. (1) Overnight Dexamethasone (Single Dose) Trial: Subjects are given dexamethasone at night, at 1 mg or 0.5-1 mg / m 2 for adults (if already serving Dalun Ding or phenobarbital etc. Medicine, should be 2 mg), children 10 micrograms / kg. And taking non-barbiturate sedatives (such as diazepam). 8 am the next morning blood, plasma cortisol concentration.