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目的:探讨血管心外膜活性物质(BVES)在胆囊癌中的表达及其意义。方法:用免疫组化法检测65例胆囊癌组织和55例良性病变胆囊组织中BVES的表达情况,并分析BVES蛋白的表达与临床病理因素的关系。结果:BVES蛋白胆囊癌组织中高表达率为20.0%(13/65),低表达率为80.0%(52/65),而在胆囊良性病变组织中高表达率为74.5%(41/55),低表达率为25.5%(14/55),两者差异有统计学意义(χ2=35.811,P<0.05)。单因素分析显示BVES表达与胆囊癌的组织分化程度、临床分期、淋巴结转移密切相关,该3因素分组间的差异均有统计学意义(均P<0.05)。结论:BVES的低表达或者表达缺失可能在胆囊癌发生、发展中起重要作用。
Objective: To investigate the expression of vascular adventitial active substance (BVES) in gallbladder carcinoma and its significance. Methods: The expression of BVES in 65 gallbladder carcinomas and 55 gallbladder tissues of benign lesions was detected by immunohistochemistry. The relationship between the expression of BVES protein and clinicopathological factors was analyzed. Results: The high expression rate of BVES protein in gallbladder carcinoma tissues was 20.0% (13/65), the low expression rate was 80.0% (52/65), while the high expression rate in gallbladder benign lesions tissues was 74.5% (41/55) The expression rate was 25.5% (14/55), the difference was statistically significant (χ2 = 35.811, P <0.05). Univariate analysis showed that the expression of BVES was closely related to the histological grade, clinical stage and lymph node metastasis of gallbladder carcinoma. There were significant differences among the three groups (all P <0.05). Conclusion: The low expression of BVES or the loss of expression may play an important role in the occurrence and development of gallbladder carcinomas.