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大多数2,5-哌嗪二酮(PDO)衍生物具有生理活性。如 bicyclomycin、antibiotic 593A、sirodesmin、spirochloride 以及 albon-oursin 等。近年来 PDO 主要用作合成非蛋白氨基酸的中间体。Sch(?)llkopf 系列报道了由PDO 制得内酰亚胺醚,在丁基锂存在下的烷基化反应,酸性水解后合成α-氨基酸。
Most 2,5-piperazinedione (PDO) derivatives are physiologically active. Such as bicyclomycin, antibiotic 593A, sirodesmin, spirochloride and albon-oursin. In recent years, PDO is mainly used as an intermediate for the synthesis of non-protein amino acids. The Sch (?) Llkopf series reports the formation of an imide ether from PDO, alkylation in the presence of butyllithium, and the synthesis of a-amino acids after acidic hydrolysis.