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目的:研究去油制霜后油脂含量不同对美洲大蠊防治CCl_4致小鼠急性肝损伤作用的影响,探索具有防治肝损伤疗效的美洲大蠊霜的油脂含量范围。方法:通过相应方法制备试验样品,采用重量法测定各样品油脂含量;经CCl_4致小鼠急性肝损伤模型考察油脂含量对其防治肝损伤药理作用的影响。结果:制得美洲大蠊原粉、3批不同含油量美洲大蠊霜及去油美洲大蠊5个样品,测得油脂含量依次分别为39.0%、31.9%、23.7%、15.0%和0.5%。与模型组比较,油脂含量为15.0%、23.7%的美洲大蠊霜组可减轻CCl_4引起的急性小鼠肝损伤,油脂组、去油粉末组、含油量为31.9%的美洲大蠊霜组及原粉末组均未表现出防治作用反而会加重肝损伤。结论:油脂含量对美洲大蠊防治CCl_4致肝损伤的药理作用有显著影响。提示对于肝损伤患者或其他疾病伴随肝损伤患者,如需以美洲大蠊全虫入药,则必需通过去油制霜炮制除去部分油脂,使其油脂含量控制在适宜范围内。为保证用药安全有效,根据试验结果暂将油脂含量范围定于15.0%~23.7%。
OBJECTIVE: To study the effect of different oil content after deoiling cream on the prevention and treatment of acute liver injury induced by CCl 4 in American cockroach and to explore the range of lipid content of the cockroach cream with prevention and treatment of liver injury. Methods: The test samples were prepared by the corresponding methods. The lipid content of each sample was determined by gravimetric method. The acute liver injury model induced by CCl_4 was used to investigate the effect of lipid content on the pharmacological effects of hepatic injury. Results: Five samples of American cockroach cream and three American cockroach creams with different oil content were obtained. The contents of oils were 39.0%, 31.9%, 23.7%, 15.0% and 0.5%, respectively. . Compared with the model group, the cockroach cream group of 15.07% and 23.7% of the American cockroach cream group can reduce the acute liver injury caused by CCl_4, the fat group, the degreasing powder group, the cockroach cream group with the oil content of 31.9% The original powder group did not show the role of prevention but will increase liver injury. Conclusion: The lipid content has a significant effect on the pharmacological effects of American cockroach to prevent and cure CCl 4 -induced hepatic injury. Tip For patients with liver injury or other diseases associated with liver injury patients, if the need for all insects American cockroach medicine, you must go through the oil frying system to remove part of the oil, so that the oil content in the appropriate range. In order to ensure safe and effective drug use, according to the test results temporarily set the oil content range of 15.0% ~ 23.7%.