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目的研究广西地区人群接种重组乙肝疫苗后无、弱应答与HLA-DRB1*11等位基因的相关性。方法选取广西籍912名健康大学生,按0,1,6方案标准全程接种重组乙肝疫苗,接种半年后采血检测血清中抗-HBs水平。对首次检测抗-HBs<10 mIU/ml者再行接种重组乙肝疫苗20 ug。4周后抗-HBs仍小于10 mIU/ml的65人作为无、弱应答组,随机抽取首次检测抗-HBs>10 mIU/ml的中、强应答者96名作为对照组。应用PCR-SSP方法检测外周血HLA-DRB1*11等位基因。结果HLA-DRB1*11等位基因在无、弱应答组的携带率为16.92%,在中、强应答组的携带率为14.58%,两组比较无统计学意义(P>0.05)。结论HLA-DRB1*11等位基因频率与广西地区人群乙肝疫苗免疫无、弱应答无明显相关性。
Objective To investigate the relationship between no-weak response and HLA-DRB1 * 11 allele in Guangxi population after inoculation of recombinant hepatitis B vaccine. Methods A total of 912 healthy college students from Guangxi were enrolled in this study. The recombinant hepatitis B vaccine was inoculated throughout the course of 0, 1, 6 protocol. Serum anti-HBs levels were measured by blood sampling six months after inoculation. The first test of anti-HBs <10 mIU / ml were re-vaccinated recombinant hepatitis B vaccine 20 ug. Sixty-six patients with anti-HBs less than 10 mIU / ml after 4 weeks were randomly selected as the control group. The peripheral blood HLA-DRB1 * 11 allele was detected by PCR-SSP method. Results The carrying rate of HLA-DRB1 * 11 allele was 16.92% in the no-weak response group and 14.58% in the strong response group. There was no significant difference between the two groups (P> 0.05). Conclusions There is no significant correlation between HLA-DRB1 * 11 allele frequency and no-immune or weak-response of hepatitis B vaccine in Guangxi population.