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目的观察As2O3与碘油联合经肝动脉化疗栓塞术后对兔VX2肝移植瘤生长及转移的作用。方法40只家兔肝内肿瘤种植后2周,随机分为5组,经肝动脉插管分别给予不同处理,实验设生理盐水灌注组、As2O3灌注组、单纯碘油栓塞组、阿霉素碘油栓塞及As2O3碘油栓塞组,As2O3的用量为2mg/kg。肿瘤种植后5周,测量动物体重,所有动物均处死,取出肝脏及双肺标本,测定肝脏的重量,计算肝移植瘤的体积、坏死面积,观察肝内、双肺及其他器官肿瘤转移的发生率。结果肿瘤植入后5周,各处理组动物体重均有明显的下降,肝脏重量增加,计算的肝指数各组分别为9.8±2.2、9.7±2.1、8.5±2.0、8.4±2.1、6.4±1.2;肿瘤体积分别为(35.5±7.6)cm3、(32.2±9.7)cm3、(21.2±8.5)cm3、(20.9±11.3)cm3、(11.8±4.0)cm3,栓塞治疗组与非栓塞治疗组间差异有统计学意义,As2O3碘油栓塞治疗组与其他组相比差异有统计学意义。平均坏死率各组间差异无明显的统计学意义。双肺转移结节的数目各组分别为52.4±32.2、51.8±26.3、54.8±29.2、53.5±30.7、19.6±17.0;转移结节的直径各组分别为(3.8±1.2)mm、(3.6±1.1)mm、(3.9±1.3)mm、(3.5±1.6)mm、(2.2±0.7)mm。As2O3碘油栓塞治疗组与其他各组相比差异有统计学意义(P<0.05)。结论As2O3与碘油联合经肝动脉栓塞治疗,可抑制肝移植瘤的生长及肺转移。
Objective To observe the effect of As2O3 and lipiodol combined with transcatheter arterial chemoembolization on the growth and metastasis of VX2 liver xenografts in rabbits. Methods Forty rabbits with intrahepatic liver tumor were randomly divided into 5 groups after 2 weeks of implantation. Hepatic arterial cannulation was used to treat the intrahepatic tumor. The rats in each group were treated with saline, As2O3, lipiodol embolism, doxorubicin Oil embolism and As2O3 lipiodol embolism group, the amount of As2O3 2mg / kg. Five weeks after the implantation of the tumor, animals were weighed and all animals were sacrificed. Liver and lung samples were taken out. The liver weights were measured. The volume and necrosis of the liver xenografts were calculated. The occurrence of tumor metastasis in the liver, lungs and other organs was observed rate. Results At 5 weeks after tumor implantation, the body weight of each treatment group decreased significantly and the weight of liver increased. The calculated liver index was 9.8 ± 2.2, 9.7 ± 2.1, 8.5 ± 2.0, 8.4 ± 2.1 and 6.4 ± 1.2 ; The tumor volume was (35.5 ± 7.6) cm3, (32.2 ± 9.7) cm3, (21.2 ± 8.5) cm3, (20.9 ± 11.3) cm3, and (11.8 ± 4.0) cm3 respectively. There was no significant difference between the embolization group and non-embolization group There was statistical significance, As2O3 lipiodol embolization group compared with other groups, the difference was statistically significant. The average necrosis rate among the groups showed no significant difference. The number of metastatic nodules was 52.4 ± 32.2,51.8 ± 26.3,54.8 ± 29.2,53.5 ± 30.7 and 19.6 ± 17.0 in each group. The diameters of metastatic nodules in each group were (3.8 ± 1.2) mm and (3.6 ± 1.1) mm, (3.9 ± 1.3) mm, (3.5 ± 1.6) mm, (2.2 ± 0.7) mm. As2O3 lipiodol embolization group compared with other groups, the difference was statistically significant (P <0.05). Conclusion As2O3 combined with lipiodol via hepatic artery embolization can inhibit the growth of liver xenografts and lung metastasis.