【摘 要】
：
Bioorthogonal reactions have attained great interest and achievements in various fields since its first appearance in 2003.Compared to traditional chemical reac
【机 构】
：
Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Scie
论文部分内容阅读
Bioorthogonal reactions have attained great interest and achievements in various fields since its first appearance in 2003.Compared to traditional chemical reactions,bioorthogonal chemical reactions mediated by transition metals catalysts can occur under physiological conditions in the living system without interfering with or damaging other biochemical events happening simultaneously.The idea of using nanomachines to perform precise and specific tasks in living systems is regarded as the frontier in nanomedicine.Bioorthogonal chemical reactions and nanozymes have provided new potential and strategies for nanomachines used in biomedical fields such as drug release,imaging,and bioengineering.Nanomachines,also called as intelligence nanorobots,based on nanozymes with bioorthogonal reactions show better biocompatibility and water solubility in living systems and perform controlled and adjustable stimuli-triggered response regarding to different physiological environments.In this review,we review the definition and development of bioorthogonal chemical reactions and describe the basic principle of bioorthogonal nanozymes fabrication.We also review several controlled and adjustable stimuli-triggered intelligence nanorobots and their potential in therapeutic and engineered applications.Furthermore,we summarize the challenges in the use of intelligence nanorobots based on nanozymes with bioorthogonal chemical reactions and propose promising vision in smart nanodevices along this appealing avenue of research.
其他文献
针对聚丙烯PP和聚甲基丙烯酸甲酯PMMA,本文开展了系统的压痕与刮擦实验,研究了压头形状对高分子材料压痕与刮擦过程中变形和失效的影响,探讨了高分子材料压痕和刮擦响应的应
本文研究了变指数拟鞅Hardy空间,给出了变指数拟鞅Hardy空间的原子分解并证明了 p(?)-拟鞅原子上次线性算子的有界性,推广了变指数鞅Hardy空间中的已知结论.“,”In this pap
本文考虑了一类非局部椭圆型方程-△u+V(x)u=(1/|x|μ*Q(x)f(u)/|x|β)Q(x)f(u)/|x|β,x∈R2,其中V是正的连续位势函数,0＜μ＜2,0≤β＜1/2,2β+μ≤2,F(s)是f(s)的原函数.假设非
在模拟大气边界层流动的风洞中,风速剖面模拟是关键技术之一。为了在风洞中实现大气边界层风速剖面的模拟,在风洞试验段内产生满足要求的风速剖面,本文针对一种基于调节片的风速剖面模拟装置进行了实验研究。这种基于调节片的风速剖面模拟装置在高度方向分为若干层,每层均由3片调节片组成,每片调节片按相同的规律开孔,且每层调节片均可独立控制。通过调节每层调节片的相对位置,使得每层通道的流通面积发生改变,使风洞在不同高度产生不同的阻塞度,引起气流流量的二次分配,同时在高度方向上的速度剪切,将气流的动能转化为湍流脉动,从而形成
Innovations in sequencing technology have generated voluminous microbial and host genomic data,making it possible to detect these genetic variations and analyze
弓网接触力是评估弓网受流质量和弓头滑板磨损寿命、诊断接触网局部缺陷的直接依据,其在线监测是未来电气化铁路发展亟待解决的关键问题之一。针对现有测试方法存在的问题,本文提出了在弓头簧片背面安装应变传感器的可行方案,避免了滑板更换对传感器带来的影响;同时,实现了加载过程中任一时刻接触点位置的直接测量,结合测点应变值,可直接反推出接触力,无需对滑板实体结构进行简化。
Single-cell RNA sequencing (scRNA-seq) is a burgeoning field where experi-mental techniques and computational methods have been under rapid evolu-tion in the pa
光聚合反应是一种复杂的物理化学反应.在特定光照下,光引发剂分解为活性自由基,引发液态聚合物单体进行链式聚合反应,形成固态高分子聚合物.在聚合过程中,随着聚合转化率(已
螺旋卷绕型纤维基人工肌肉是模仿天然肌肉的新型致动器,在柔性驱动领域具有广阔的应用前景。通过将尼龙6纤维和铜丝复合卷绕,制备了电阻丝附着型纤维基人工肌肉;搭建了表征人工肌肉致动特性的实验平台,对人工肌肉的致动特性进行研究,发现致动效率与输入功率、螺旋直径有关。对螺旋卷绕型纤维基人工肌肉的致动特性进行理论分析,预测了致动应变随温度的变化规律,与实验结果吻合;并讨论了手性、纤维偏转角等参数对人工肌肉致动性能的影响。本研究提供了高性能纤维基人工肌肉的制备和测试方法,可为其先进结构设计及性能调控提供参考。
在数学史上,有些著名的猜想尽管被推翻了,却仍然发挥着作用,并推动本学科的发展,可谓是散发着无尽的魅力.例如,1640年,法国数学家费马(Fermat)曾给出以下公式,即Fn=22n+1.后