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目的：探讨淋巴细胞亚群在多发性硬化免疫病理中的作用及胎儿胸腺细胞移植的影响。方法：采用间接免疫荧光法对胎儿胸腺细胞悬液治疗前后多发性硬化患者淋巴细胞亚群进行研究。结果：ＭＳ活动期患者外周血ＣＤ＋４、ＣＤ＋８较对照组降低，ＣＤ＋４／ＣＤ＋８比值较对照组明显升高。经胚胎胸腺细胞移植治疗后，ＣＤ＋８细胞较治疗前升高，而ＣＤ＋４／ＣＤ＋８比值下降。结论：多发性硬化发病与淋巴细胞免疫有关，给予胎儿胸腺细胞移植治疗，具有免疫重建作用。
Objective: To investigate the role of lymphocyte subsets in multiple sclerosis immunopathology and the effects of fetal thymocyte transplantation. Methods: The indirect immunofluorescence method was used to study the lymphocyte subsets of multiple sclerosis patients before and after treatment of fetal thymocyte suspension. Results: The levels of CD + 4 and CD + 8 in the peripheral blood of MS patients were lower than those in the control group, and the ratio of CD + 4 / CD + 8 was significantly higher than that in the control group. After embryo thymocyte transplantation, CD + 8 cells increased compared with those before treatment, while the ratio of CD + 4 / CD + 8 decreased. Conclusion: The pathogenesis of multiple sclerosis is related to lymphocyte immunization. It gives fetal thymocyte transplantation and possesses immune reconstitution.