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1971年Combes首次从1例成人膜性肾病肾活检标本证实肾小球内有HBsAg沉积,从而论证乙型肝炎(乙肝)抗原在某些肾炎中的致病作用,也为某些膜性肾病找到了具体的发病原因。此后有关乙型肝炎相关性肾炎(乙肝肾炎)的报告逐渐增多。1978年以前文献报告经肾活检证实的乙肝肾炎28例,其中膜性增殖性肾炎15例,膜性肾炎8例,余为其他类型肾炎。1978～1983年日本、法国、波兰、南非及台湾学者相继对小儿乙肝肾炎开展更深入的研究,发现小儿乙肝肾炎主要病理组织类型为膜性肾病,现以上述5个报告共88例儿童乙肝膜性肾病为基础,结合有关文献,着重阐述本病近来的研究进展。
In 1971, Combes demonstrated for the first time that HBsAg deposition was present in glomeruli from an adult membranous nephropathy kidney biopsy, demonstrating the pathogenic role of Hepatitis B (hepatitis B) antigen in some glomeruli and also for some membranous nephropathy The specific cause of the disease. Since then, reports of hepatitis B-related nephritis (hepatitis B nephritis) have gradually increased. Before 1978 literature reports confirmed by renal biopsy in 28 cases of hepatitis B nephritis, membranous proliferative glomerulonephritis in 15 cases, membranous nephritis in 8 cases, more than the other types of nephritis. From 1978 to 1983, scholars from Japan, France, Poland, South Africa and Taiwan successively conducted a more in-depth study on children with hepatitis B and found that the main pathological type of hepatitis B in children was membranous nephropathy. A total of 88 children with hepatitis B Nephropathy, based on the relevant literature, focusing on the recent progress of this disease.