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1978年,中华医学杂志刊登了题为“一种新的男性节育药——棉酚”一文,首次报道棉酚对男性的节育作用。棉酚作为棉籽饲料中的毒性成分早已广泛研究并积累了大量的资料,但作为男性节育药试用于临床是新的发现,这引起各国生殖生物学家特别是美国同行们的重视,他们以极大的兴趣和怀疑,开始研究棉酚对男性生殖的影响。本文综述近二年来有关棉酚抗生育的国外资料,亦包括作者在国外的一些工作。一、棉酚抗生育作用的比较观察1.同一批实验中,比较金色田鼠、大鼠和兔或金色田鼠、大鼠和小鼠对棉酚的反应,结果证明金色田鼠对棉酚的抗生育作用较
In 1978, the Chinese Medical Journal published an article titled “A New Male Birth Control - Gossypol”, reporting for the first time the effect of gossypol on male birth control. As a toxic component of cottonseed feed, gossypol has extensively studied and accumulated a great deal of data, but it is a new finding that clinical trial of maleate as a birth control drug has attracted great attention from reproductive biologists in various countries, especially those in the United States. Big interest and suspicion, began to study gossypol male reproductive impact. This review summarizes the foreign data on the antifertility of gossypol in the past two years and also includes some of the author’s work abroad. First, the gossypol comparative study of anti-fertility 1. The same batch of experiments, the comparison of golden vole, rat and rabbit or golden vole, rat and mouse response to gossypol, the results prove that Golden Microtus to gossypol resistance Role than