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两种环核苷酸(cAMP和cGMP)在中枢神经系统中的作用具有转递不同神经介质的功能。脊髓、延髓、下丘脑,大脑皮层等各级中枢内除有这两种环核苷酸的分布外,同时也有分解cAMP的磷酸二酯酶的分布,表明环核苷酸在心血管调节中枢内可能具有重要作用。因此,我们首先给大白鼠侧脑室内注射dbcAMP、磷酸二酯酶抑制剂氨茶碱以及磷酸二酯酶激动剂咪唑,以期通过药理的方法来改变大鼠脑内外源性和内源性cAMP水平,观
The role of both cyclic nucleotides (cAMP and cGMP) in the central nervous system has the function of transmitting different neural mediators. Spinal cord, medulla oblongata, hypothalamus, cerebral cortex and other central levels in addition to the distribution of these two cyclic nucleotides, but also the decomposition of phosphodiesterase cAMP distribution, suggesting that cyclic nucleotides in the cardiovascular regulatory center may Has an important role. Therefore, we first injected intracerebroventricular injection of dbcAMP, phosphodiesterase inhibitor aminophylline and phosphodiesterase agonist imidazole into the lateral ventricle in order to change the exogenous and endogenous cAMP level in rat brain through pharmacological methods View