论文部分内容阅读
大量的研究证明,严格的血糖控制可以减少或延缓1型和2型糖尿病慢性并发症的发生、发展。然而,目前胰岛素强化治疗方案又不可避免地增加了低血糖事件发生的危险,由于受药物动力学的限制,普通胰岛素皮下注射并不能准确模拟胰岛素生理分泌模式,它具有吸收慢、起效迟的特点,患者必须在餐前30分钟注射,才能保证胰岛素峰值浓度与餐后血糖高峰相吻合。因此,非生理性胰岛素的补充其作用受局限,且不可避免的造成患者餐后高血糖和药物吸收后低血糖的发
A large number of studies have shown that strict glycemic control can reduce or delay the occurrence and development of chronic complications of type 1 and type 2 diabetes. However, the current insulin intensive treatment program inevitably increases the risk of hypoglycemic events. Due to the limitation of pharmacokinetics, ordinary insulin subcutaneous injection does not accurately simulate the physiological pattern of insulin secretion, which has slow absorption and delayed onset Characteristics, patients must be injected 30 minutes before meals, in order to ensure peak insulin concentration and postprandial blood glucose peak coincide. Thus, the effects of non-physiological insulin supplementation are limited and inevitably lead to postprandial hyperglycemia and hypo-glycaemia after drug absorption