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目的:通过平行比较、动态观察研究辛苍汤鼻腔灌洗的临床疗效。方法:136例有鼻部症状的哮喘患儿随机分为治疗组和对照组,分别给予“辛苍汤”和生理盐水鼻腔灌洗,隔日1次,1个月为1个疗程,共治疗2个疗程。在治疗前、治疗1、2个疗程后分别观察患儿临床症状、检测鼻腔灌洗液及血清中ECP水平,并监测肺功能。结果:两组间在治疗前各项指标无差异(P>0.05);经1个和2个疗程的干预,两组的四项指标均较治疗前显著改善(P<0.05);但治疗组疗效明显优于对照组(P<0.05)。结论:辛苍汤鼻腔灌洗能明显改善哮喘患儿临床症状和肺功能、降低鼻腔灌洗液及血清ECP水平,具有抑制气道内慢性炎症、降低气道高反应性,疗效优于生理盐水灌洗。
OBJECTIVE: To observe the clinical effect of Xincang decoction nasal lavage by parallel comparison and dynamic observation. Methods: One hundred and sixty-six asthmatic children with nasal symptoms were randomly divided into treatment group and control group, which were given “Xin Cang Decoction” and nasal lavage with saline respectively, once every other day and one month as a course of treatment Treatment of 2 courses. Before treatment, the clinical symptoms of children were observed after treatment for 1 and 2 courses, the nasal lavage fluid and serum ECP levels were measured, and lung function was monitored. Results: There was no significant difference between the two groups before treatment (P> 0.05). After one and two courses of intervention, the four indexes in both groups were significantly improved (P <0.05), but the treatment group The curative effect was obviously better than the control group (P <0.05). CONCLUSIONS: Xincang Tang nasal lavage can significantly improve the clinical symptoms and pulmonary function in children with asthma, reduce nasal lavage fluid and serum ECP levels, inhibit chronic airway inflammation and reduce airway hyperresponsiveness, the effect is better than saline irrigation wash.