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采用比色法对４２例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者及３６例正常人血清一氧化氮（ＮＯ）水平进行了检测。结果显示：ＮＩＤＤＭ患者血清ＮＯ水平明显高于正常人（Ｐ＜０．００１）；ＮＩＤＤＭ伴血管并发症者与无血管并发症者相比，血清ＮＯ水平的升高更为明显（Ｐ＜０．０５）；ＮＩＤＤＭ患者血清ＮＯ与空腹血糖、果糖胺及病程均无显著相关性（Ｐ＞０．０５）。提示ＮＯ可能参与了ＮＩＤＤＭ及其慢性并发症的发生、发展
The serum levels of nitric oxide (NO) in 42 non-insulin dependent diabetes mellitus (NIDDM) patients and 36 healthy controls were measured by colorimetry. The results showed that the serum NO level in patients with NIDDM was significantly higher than that in normal people (P <0.001). Compared with those without vascular complications, the serum NO levels increased more significantly in NIDDM patients with vascular complications (P <0.001). There was no significant correlation between serum NO and fasting blood glucose, fructosamine and duration of disease in NIDDM patients (P> 0.05). Suggesting that NO may be involved in the occurrence and development of NIDDM and its chronic complications