广东省2003年急性弛缓性麻痹病例病原流行病学分析

• 作 者: 郑焕英 黄平 陈秋霞 林永杰 柯昌文 罗耀星
• 机 构: 广东省疾病预防控制中心,广东省疾病预防控制中心,广东省疾病预防控制中心,广东省疾病预防控制中心,广东省疾病预防控制中心,广东省疾病预防控制中心 广州510300,广州510300,广州510300,广
• 出 处: 中国计划免疫
• 发表日期: 2004年06期
• 关键词: 脊髓灰质炎病毒 急性弛缓性麻痹 残留麻痹 脊灰 分离率 粪便标本 减毒活疫苗 病原学监测 病例监测 免疫史

对广东省 2 0 0 3年急性弛缓性麻痹 (AFP)病例进行病原流行病学分析。采集 2 79例AFP病例粪便标本 ,分离到脊髓灰质炎 (脊灰 )病毒 (PV) 2 5株 ,阳性率为 8 96 %,均为疫苗株。其中PVⅡ型 1 4株 ,占 5 6 %。分离到非脊灰肠道病毒 (NPEV) 1 7株 ,阳性率为 6 0 9%。对 2 0 0 3年AFP病例的免疫史、性别、年龄与病原学结果之间的关系进行了分析 ,结果显示 :口服脊灰减毒活疫苗“零”剂次免疫的AFP病例的PV分离率依次高于 1～ 2次和≥ 3次免疫者 ,分别为 4 3 75 %、2 2 2 2 %和 2 37%;1 8例 6 0d后随访残留麻痹的病例PVⅡ分离率为 38 89%。

Pathogenic epidemiological analysis of acute flaccid paralysis (AFP) in Guangdong Province in 2003 was conducted. Stool samples from 2 79 cases of AFP were collected and 25 polio (polio) viruses (PVs) were isolated. The positive rate was 8 96%. All were vaccine strains. Of which PV Ⅱ type 14 strains, accounting for 56%. Seventeen isolates of non-polio enterovirus (NPEV) were isolated and the positive rate was 60.9%. The relationship between the history of immunization, sex, age and pathogenicity of AFP cases in 2003 was analyzed. The results showed that PV isolation rate of AFP cases vaccinated with zero dose of live attenuated oral poliomyelitis vaccine The rate of PVⅡseparation was 38 89% in cases of residual paralysis after 60 days, followed by 4 3 75%, 2 2 2 2% and 2 37% respectively.