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蛋白质药物大多经胃肠外给药,为减少长期注射引起的健康危害,迫切需要研究经胃肠道途径给药并发展具有控释作用的制剂。本研究的目的就是以牛血清蛋白(BSA)为模型蛋白,调查果胶以果胶酸钙凝胶(CPG)小球的形式,用于蛋白质口服给药系统的适用性。制备CPG小球利用低酯果胶的?..
Most of the protein drugs are administered parenterally. To reduce the health hazard caused by long-term injection, there is an urgent need to study the administration via the gastrointestinal route and the development of preparations with controlled release. The purpose of this study was to investigate the suitability of pectin in the form of calcium pectate calcium gels (CPG) pellets for oral administration of protein using bovine serum albumin (BSA) as a model protein. Preparation of CPG pellets using low ester pectin?