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药物在体内主要是通过肾脏、胆道和乳腺等途径排泄。药物经肝转化,以代谢物或原形泌入胆汁,经胆总管排入十二指肠,其中一部分被小肠重吸收,由门静脉回流入肝,然后再经胆汁排入肠腔。如此往复,就形成肝肠循环。药物随胆汁排泄的过程又称胆的廓清,其廓清(率)能力可由下式计算: 胆廓清=(胆法流量×胆法中药物尝试)╱血浆中药物浓度在人体,胆汁的流量常稳定在0.5～0.8 ml/min,药物在胆汁中的浓度相当或低于血浆中浓度。一般说胆的廓清能力较低,但由于药物在由胆汁转运的过程中被高度浓缩,故可以说胆的廓清能力又相当高。实
Drugs in the body mainly through the kidneys, biliary and breast and other means of excretion. The drug is converted by the liver, secreted into the bile by metabolites or the prototype, and discharged into the duodenum through the common bile duct. Some of it is reabsorbed by the small intestine and flows back into the liver through the portal vein and then into the intestine through the bile. So reciprocate, the formation of enterohepatic circulation. The process of drug excretion with bile, also known as gall bladder clearance, the capacity of its clearance (rate) can be calculated by the following formula: bile clearance = (bile flow × Gallbladder medicine try) / plasma drug concentration in the body, the bile flow often stable At 0.5 to 0.8 ml / min, the concentration of drug in the bile is comparable to or lower than the plasma concentration. In general, the ability to clear the gall is low, but because the drug is highly concentrated in the process of being transported by the bile, it can be said that the gall bladder clearance ability is quite high. real