氨基酸的生物合成途径(上)

• 作 者: 大石邦夫 王建华
• 出 处: 国外医药.合成药.生化药.制剂分册
• 发表日期: 1985年02期
• 关键词: 生物合成途径 异白氨酸 抗代谢物 鸟氨酸 氨基酸 谷氨酸发酵 野生菌株 变异 精氨酸 生物合成

一、前言利用野生菌株进行谷氨酸发酵的报道最早见于1957年,其后1957～1961年又报道了利用变异菌株进行高丝氨酸、赖氨酸、苏氨酸、缬氨酸、异白氨酸、鸟氨酸、精氨酸等的发酵生产。但在不久前,除少数例外,关于氨基酸的生物合成途径尚有许多不清楚的部分,甚至连合成与分解的途径不同也未充分了解。五十年代氨基酸生物合成途径研究的急剧进步,多数是靠了(1)利用变异菌株、(2)利用同位素和(3)利用抗代谢物这三个手段,

First, the introduction of wild strains of glutamate fermentation was first reported in 1957, 1957 ~ 1961 was reported after the use of mutant strains for homoserine, lysine, threonine, valine, isoleucine , Ornithine, arginine fermentation production. But not long ago, with a few exceptions, there are still many unclear parts about the amino acid biosynthesis pathway, and even the differences between synthesis and decomposition are not fully understood. The dramatic advances in amino acid biosynthesis pathways of the 1950s have been largely based on (1) the use of mutant strains, (2) the use of isotopes and (3) the use of antimetabolites,