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目的:探讨甲状腺功能亢进症（甲亢）患者生活质量及其影响因素。方法:选取2017年6月至2019年6月海南医学院第一附属医院收治的初次诊断为甲亢的患者作为研究对象，采用世界卫生组织生存质量简表（WHOQOL-BREF）中文版评估患者的生活质量；采用汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评估患者的心理状态；采用单因素分析比较不同生活质量患者之间一般资料（年龄、性别、病程、婚姻状况、文化程度、职业、家庭月收入、家庭关系、甲状腺眼病、实验室检查、甲状腺危象、焦虑水平、抑郁水平）的差别；以多因素logistic回归分析影响甲亢患者生活质量的相关因素。结果:共纳入120例患者，年龄为（45.42 ± 6.38）岁；男42例，女78例。所有患者WHOQOL-BREF评分为（76.58 ± 10.42）分，范围为25 ~ 106分，其中高分（≥80分）患者49例（40.83%），低分（< 80分）患者71例（59.17%）。单因素分析显示，不同婚姻情况、文化程度、家庭月收入、家庭关系、合并甲状腺眼病、FTn 3、FTn 4、焦虑水平、抑郁水平间生活质量评分分布比较差异均有统计学意义（n P均< 0.05）。多因素分析显示，合并甲状腺眼病、离异或丧偶、家庭月收入< 2 000元、家庭关系不和睦、存在抑郁或焦虑情绪、FTn 4异常、FTn 3异常是影响甲亢患者生活质量的危险因素（n P均< 0.05）。n 结论:甲亢患者的总体生活质量偏低，尤其是合并甲状腺眼病、离异或丧偶、家庭月收入< 2 000元、家庭关系不和睦、存在抑郁或焦虑情绪、FTn 4或FTn 3异常的患者。n “,”Objective:To explore the quality of life and its influencing factors in patients with hyperthyroidism.Methods:From June 2017 to June 2019, patients with hyperthyroidism who were first diagnosed in the First Affiliated Hospital of Hainan Medical College were selected as the research objects, and the quality of life of the patients was assessed by the Chinese version of World Health Organization Quality of Life Brief Scale (WHOQOL-BREF). Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate the psychological status of the patients. Univariate analysis was used to compare the differences of general information (age, gender, course of disease, marital status, education level, occupation, monthly family income, family relationship, thyroid ophthalmopathy, laboratory examination, thyroid crisis, anxiety level, and depression level) among patients with different quality of life. Multivariate logistic regression analysis was used to analyze the related factors affecting the quality of life of patients with hyperthyroidism.Results:There were 120 patients, aged (45.42 ± 6.38) years old, including 42 males and 78 females. The WHOQOL-BREF score was (76.58 ± 10.42) points, ranging from 25 to 106 points. Among them, 49 cases (40.83%) had high scores (≥80 points) and 71 cases (59.17%) had low scores (<80 points). Univariate analysis showed that there were differences in the quality of life among different marital status, education level, monthly family income, family relationship, thyroid ophthalmopathy, FTn 3, FTn 4, anxiety level and depression level (n P < 0.05). Multivariate analysis showed that thyroid ophthalmopathy, divorce or widowhood, monthly family income < 2 000 yuan, family disharmony, depression or anxiety, abnormal FT n 4 and FTn 3 were the risk factors affecting the quality of life of patients with hyperthyroidism (n P < 0.05).n Conclusion:The overall quality of life of patients with hyperthyroidism is low, especially those with thyroid ophthalmopathy, divorce or widowhood, monthly family income < 2 000 yuan, family disharmony, depression, anxiety, FT n 4 or FTn 3 abnormalities.n