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本文简述了以下三方面问题:一、非离子表面活性剂的自氧化:在贮存过程中由于自氧化生成过氧化物,改变了它本身的化学结构和物理性质,并且在制剂中会造成可氧化药物的不稳定。还阐述了自氧化反应的机制、生成物和影响固素。二、过氧化物的测定:使用碘量法和分光光度法,并对两种方法稍加比较。三、过氧化物的去除:有饱和氯化钠溶液萃取法和加入抗氧剂或过氧化氢酶等预处理法两种。
This article briefly describes the following three issues: First, the non-ionic surfactant self-oxidation: due to self-oxidation during storage to produce peroxide, changing its chemical structure and physical properties, and will result in the preparation of Oxidative drug instability. Also describes the mechanism of autoxidation, products and affect the solid content. Second, the determination of peroxide: the use of iodometry and spectrophotometry, and a slight comparison of the two methods. Third, the removal of peroxide: a saturated sodium chloride solution extraction method and adding antioxidants or catalase pretreatment two.