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目的探讨不同类型老年心力衰竭患者心电图QRS波时限与血浆N末端B型利钠肽原(NT-pro BNP)水平和心功能的关系。方法老年心力衰竭患者140例为研究组,根据衰竭类型将患者分为收缩组(n=66)和舒张组(n=74),另选取同期非心力衰竭患者100例为对照组,应用美国纽约心脏病协会(NYHA)分级评价心功能,检测所有入选者心电图QRS波时限、左室射血分数(LVEF)和血浆NT-pro BNP水平。结果研究组QRS波时限显著长于对照组,收缩组QRS显著长于舒张组,研究组NT-pro BNP水平显著高于对照组,NYHA显著高于对照组,LVEF显著低于对照组,且收缩组显著优于舒张组(P<0.05);相关性分析显示:QRS波时限与NT-pro BNP水平和NYHA分级呈正相关(P<0.05),与LVEF呈负相关关系(P<0.05)。结论老年心力衰竭患者QRS波时限较长,血浆NT-pro BNP水平较高,且不同类型心力衰竭患者也存在差异,QRS波时限及血浆NTpro BNP水平能反映患者心功能。
Objective To investigate the relationship between ECG QRS duration and plasma N-terminal pro-brain natriuretic peptide (NT-pro BNP) levels and cardiac function in different types of elderly patients with heart failure. Methods A total of 140 elderly patients with heart failure were included in the study. According to the type of failure, patients were divided into two groups: n = 66 for contraction and n = 74 for vasorelaxation. Another 100 patients with non-heart failure during the same period were selected as control group. Cardiac function was assessed by the Heart Association (NYHA) grading, QRS wave duration, left ventricular ejection fraction (LVEF), and plasma NT-pro BNP levels were measured in all enrolled patients. Results The QRS wave length in the study group was significantly longer than that in the control group. The QRS in the contraction group was significantly longer than that in the diastolic group. The NT-pro BNP level in the study group was significantly higher than that in the control group. The NYHA was significantly higher than that in the control group. Correlation analysis showed that the QRS wave duration was positively correlated with NT-pro BNP level and NYHA classification (P <0.05), and negatively correlated with LVEF (P <0.05). Conclusions The elderly patients with chronic heart failure have longer QRS duration, higher plasma NT-pro BNP level, and different types of heart failure patients. QRS wave duration and plasma NTpro BNP level can reflect the cardiac function of patients.