论文部分内容阅读
目的:观察加味大柴胡汤对高胆固醇饲喂的家兔(AS)形成及C反应蛋白的影响。方法:制作大耳白兔AS模型,10周后进行血脂、C反应蛋白检测、病理检查。结果:大柴胡汤治疗组血脂水平,AS斑块程度,C反应蛋白(CRP)均较动脉粥样硬化对照组差异有显著性(P<0.01)。结论:提示大柴胡汤具有抗AS作用,加味大柴胡汤能预防高胆固醇饮食家兔动脉粥样硬化形成的机制与降低炎症标志物CRP相关。
OBJECTIVE: To observe the effect of Modified Dachaihu Decoction on the formation of rabbits with high cholesterol and the formation of C-reactive protein. METHODS: A rabbit model of large ears was made and 10 weeks later, lipids, C-reactive protein and pathological examinations were performed. Results: The levels of blood lipids, degree of AS plaques, and C-reactive protein (CRP) in Dachaihu decoction group were significantly higher than those in atherosclerosis control group (P<0.01). Conclusion: It is suggested that Dachaihu Decoction has anti-AS effect. Modified Dachaihu Decoction can prevent the formation of atherosclerosis in hypercholesterolemic diet rabbits and is associated with the decrease of inflammation markers CRP.