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目的分析我院抗菌药物用量与常见革兰氏阴性菌耐药相关性,为临床合理用药提供可靠依据。方法采用回归性分析方法对我院2015年1月-2016年12月期间送检的病原菌培养结果、同期抗菌药物累计使用频度以及细菌耐药率等进行分析总结。结果抗菌药物总用药频度逐年减少,从2015年的237106下降至2016年的145672。鲍曼不动杆菌与铜绿假单胞菌对哌拉西林他唑巴坦耐药率较高,对β-内酰胺类抗菌药耐药率较低;哌拉西林使用量与鲍曼不动杆菌耐药率、头孢吡肟使用量与阴沟肠杆菌耐药率呈负相关。结论抗菌药物使用频度逐年下降,部分细菌的耐药率与抗菌药物使用量呈正相关,而部分呈负相关,少部分无明显相关性。
Objective To analyze the correlation between antimicrobial dosage in our hospital and drug resistance of common Gram-negative bacteria and provide a reliable basis for clinical rational drug use. Methods The results of pathogen culture, the cumulative frequency of antibacterial drugs and the rate of bacterial resistance in our hospital from January 2015 to December 2016 were analyzed by regression analysis. Results The total frequency of antimicrobial drugs decreased year by year, from 237,106 in 2015 to 145,672 in 2016. Acinetobacter baumannii and Pseudomonas aeruginosa had higher drug resistance to piperacillin and tazobactam and lower resistance to β-lactam antibacterials. The use of piperacillin and Acinetobacter baumannii Resistance rate, the use of cefepime and Enterobacter cloacae resistance was negatively correlated. Conclusions The frequency of antimicrobial use declines year by year. The resistance rate of some bacteria is positively correlated with the amount of antibacterials used, while some of them are negatively correlated with the other few without significant correlation.