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目的分析氟喹诺酮类与茶碱类联用致不良事件的特点,为临床合理用药提供参考。方法检索Pub Med、CNKI、VIP、CMB和万方数据有关氟喹诺酮类与茶碱类联用致不良事件的文献进行统计学分析。结果各种氟喹诺酮类与茶碱类联用均可致不良事件,其中左氧氟沙星联用氨茶碱最多;老年患者较易发生,平均年龄(64.5±19.4)岁;发生不良事件的平均时间为(3.35±1.45)d,多为迟发性,临床以心律失常和精神异常最为常见,一旦出现不良事件立即停药,大部分不适症状即刻缓解。结论不良事件可能是因为氟喹喏酮类与茶碱类相互影响其体内代谢动力学参数,使体内血药浓度增加所致。因此老年患者应适当减少用药剂量或延长给药间隔,同时对有心脑血管病史和精神病史的患者慎用。
Objective To analyze the characteristics of the adverse events caused by fluoroquinolones and theophylline in order to provide a reference for clinical rational drug use. Methods We searched PubMed, CNKI, VIP, CMB and Wanfang data for statistical analysis of literature related to adverse events caused by fluoroquinolones and theophylline. Results All kinds of fluoroquinolones combined with theophylline could cause adverse events, of which levofloxacin combined with aminophylline was the most, elderly patients were more likely to have an average age of (64.5 ± 19.4) years, and the average time of occurrence of adverse events was ( 3.35 ± 1.45) d, mostly delayed, clinical arrhythmias and mental disorders are the most common, once the adverse events immediately stop taking, most of the discomfort immediately relief. Conclusions Adverse events may be due to the mutual influence of fluoroquinolone and theophylline on the in vivo pharmacokinetic parameters, resulting in the increase of the blood concentration in the body. Therefore, elderly patients should be appropriate to reduce the dose or extend the dosing interval, at the same time have a history of cardiovascular disease and psychiatric history of patients with caution.