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目的探讨低密度脂蛋白对冠状动脉粥样硬化性心脏病(CHD)患者的影响。方法选取2012年1月至2013年1月吉林省长春市中医院收治的74例CHD患者作为观察组,选择同期75例健康体检者为对照组。观察组患者依据冠脉造影检查依次分为单支病变22例、双支病变31例、多支病变21例。所有检测者均在清晨空腹状态下抽取静脉血5 ml,检测其低密度脂蛋白胆固醇(LDL-C)、氧化型低密度脂蛋白胆固醇(ox-LDL-C)、小而密低密度脂蛋白胆固醇(sd LDL-C)水平。结果观察组患者的LDL-C、ox-LDL-C、sd LDL-C水平均明显高于对照组,差异均有统计学意义(均P<0.05);多支病变患者的LDL-C、ox-LDL-C、sd LDL-C水平均明显高于单支及双支病变,呈递增趋势,差异均有统计学意义(均P<0.05)。结论 LDL-C、ox-LDL-C、sd LDL-C均与CHD密切相关,其不但能够辅助CHD诊断,且对病变程度也有良好评估作用。
Objective To investigate the effect of low density lipoprotein on patients with coronary atherosclerotic heart disease (CHD). Methods From January 2012 to January 2013, 74 CHD patients admitted to Changchun Hospital of Traditional Chinese Medicine in Jilin Province were selected as the observation group and 75 healthy subjects were selected as the control group. According to coronary angiography, the observation group patients were divided into single-vessel disease, 22 cases, double-vessel disease in 31 cases and multi-vessel disease in 21 cases. All the test subjects took venous blood 5 ml in the morning fasting state and detected the levels of LDL-C, ox-LDL-C, small and dense low-density lipoprotein Cholesterol (sd LDL-C) levels. Results The levels of LDL-C, ox-LDL-C and sd LDL-C in the observation group were significantly higher than those in the control group (all P <0.05). LDL-C, ox -LDL-C, sd LDL-C levels were significantly higher than the single and double vessel lesions, showing an increasing trend, the differences were statistically significant (P <0.05). Conclusions LDL-C, ox-LDL-C and sd LDL-C are all closely related to CHD, which not only can assist the diagnosis of CHD, but also have a good evaluation of the degree of lesion.