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目的探讨急性脑血管疾病与肿瘤坏死因子(TNF-α)的相关性。方法回顾性分析2012年5月至2015年5月沈阳市第七人民医院神经内科收治的40例急性脑血管病患者(研究组),另选取同期来我院体检的40例作为健康人员(对照组),运用酶联免疫吸附试验(ELISA)检测两组受检者的TNF-α水平。结果研究组患者不同疾病类型、神经功能、疾病严重程度患者的TNF-α水平均明显高于对照组,差异均有统计学意义(均P<0.05);研究组中,脑梗死患者的TNF-α水平明显高于脑出血患者,神经功能恶化患者的TNF-α水平明显高于非恶化患者,重度患者的TNF-α水平明显高于轻中度患者,差异均有统计学意义(均P<0.05)。结论急性脑血管疾病严重程度、神经功能均与TNF-α水平呈正相关。
Objective To investigate the relationship between acute cerebrovascular disease and tumor necrosis factor (TNF-α). Methods Forty patients with acute cerebrovascular disease (study group) admitted to the Department of Neurology, Shenyang Seventh People’s Hospital from May 2012 to May 2015 were retrospectively analyzed. Forty patients with physical examination in our hospital were selected as healthy persons (control group Group). The levels of TNF-α in the two groups were detected by enzyme linked immunosorbent assay (ELISA). Results The levels of TNF-α in patients with different disease types, neurological function and disease severity in the study group were significantly higher than those in the control group (all P <0.05). In the study group, TNF- α levels were significantly higher than those in patients with cerebral hemorrhage. The levels of TNF-α in patients with neurological deterioration were significantly higher than those in non-worsening patients. The levels of TNF-α in severe patients were significantly higher than those in mild to moderate patients (all P < 0.05). Conclusion The severity of acute cerebrovascular disease and neurological function are positively correlated with the level of TNF-α.