Duchenne肌营养不良的强的松治疗与非治疗组肌活检的单核细胞分析

• 作 者: 马平
• 出 处: 国外医学.神经病学神经外科学分册
• 发表日期: 1992年04期
• 关键词: Duchenne 肌营养不良 肌活检 形态学改变 安慰剂对照 随机双盲 细胞因子 二头肌 炎性细胞 淋巴细胞减少

Duchenne肌营养不良(DMD)患者经强的松治疗后提高了平均肌力和时限功能(timed function).作者为了研究其机理和形态学改变,进行了随机双盲安慰剂对照实验.受试者33名(5～15岁),分3组,安慰剂组12人,小剂量组9人(强的松0.75mg/kg/d);大剂量组12人(强的松1.5mg/kg/d);历时6月.实验结束时进行肌活检,取肱二头肌:安慰剂组8人,小剂量组5人,大剂量组6人;股四

Duchenne Muscular Dystrophy (DMD) patients treated with prednisone increased mean muscle strength and timed function. In order to investigate its mechanism and morphological changes, a randomized, double-blind, placebo-controlled trial was performed. Subjects 33 (5-15 years old) were divided into 3 groups, 12 in placebo group and 9 in low dose group (prednisone 0.75 mg / kg / d); 12 in large dose group (prednisone 1.5 mg / kg / d); lasted for 6 months.At the end of the experiment, muscle biopsy was taken, biceps: 8 in placebo group, 5 in low dose group, 6 in high dose group;